Mouse Anti-Human CD34-FITC

DESCRIPTION
Clone581 (Class III)
Ig Isotype Mouse IgG1
SpecificityHuman CD34 Class III epitope
CD34 is a 110-120 kDa heavily O-glycosylated type I transmembrane glycoprotein. It is expressed on a small subpopulation (2-4%) of bone marrow cells including hematopoietic stem cells, small vessel endothelial cells and tumors of epithelial origin, and a subset of fibroblasts. It is believed that hematopoietc CD34 plays a role in modulating adhesion and as well as signal transduction through its phosphorylation by activated protein kinase C. The monoclonal antibody 581 reacts to the class III CD34 epitope which is resistant to neuraminidase, chymopapain and glycoprotease.1-8
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